Julie Lin and Gary C. Curhan
This study identified 3318 women participating in the Nurses' Health Study with data on soda intake and albuminuria
Results
Consumption of ≥2 servings per day of artificially sweetened (diet) soda was independently associated with eGFR decline ≥30% (OR 2.02, 95% CI 1.36 to 3.01) and ≥3 ml/min per 1.73 m2 per year (OR 2.20, 95% CI 1.36 to 3.55). No increased risk for eGFR decline was observed for <2 servings per day of diet soda. No associations were noted between diet soda and MA or sugar soda and MA or eGFR decline.
Discussion
Our results did not confirm the previously reported association between sugar soda and albuminuria, but we report a novel finding that ≥2 servings per day of artificially sweetened soda was associated with faster kidney function decline.
The observed association between diet soda and faster kidney function decline was not an a priori hypothesis and may be subject to incomplete adjustment for confounding despite our efforts in constructing additional models that included nutrients, foods, and diet quality. We would also emphasize that causality cannot be established from an analysis of an observational cohort study, and that higher consumption of diet soda may be a marker of unmeasured characteristics that put women at higher risk for progressive kidney function decline.
However, if there is a causal association, we cannot determine if there is a specific type of artificial sweetener that may be associated with kidney function decline or even if it is an artificial sweetener or another ingredient in diet soda not found in sugar soda. Aspartame and saccharin were the primary artificial sweeteners used in carbonated low-calorie soft drinks in the 1980s and 1990s (The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control29), which pertain to the years assessed by the FFQs used for the kidney function decline analyses.
In summary, ≥2 servings per day of artificially sweetened soda was significantly associated with faster kidney function decline in older women with preserved kidney function. In light of the documented increase in soft drink consumption across all age groups between 1977 and 2001 (The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control32), this finding generates a new hypothesis about diet soda and renal decline and has potential important public health implications if further research can establish the generalizability of this finding in men and non-whites as well as a causal relationship between artificially sweetened soda and kidney function decline.
Conclusions
Consumption of ≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.
Read the full publication at : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022238/
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